Building a National Genomic Infrastructure as Part of the European 1+ Million Genomes Initiative:
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Whole-genome sequencing (WGS) is a powerful tool for research and clinical applications. In this study, we used WGS to build a high-resolution Latvian genomic reference as part of the European 1+ Million Genomes initiative. Using the MGI T7 platform, we sequenced 3,500 individuals, generating high-quality data for population genetics and a national genome system. Our findings reveal unique Latvian ancestry and demonstrate WGS utility in identifying both monogenic and polygenic contributions to inherited metabolic and lipid disorders, enhancing disease prediction and clinical decision-making.
Prof. Janis Klovins, Professor & Head of the Scientific Council @ Latvian Biomedical Research & Study Centre, Latvia
