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Revolutionizong Diagnostics Whole Exome Seqeucning with DNBSEQ

4 juil. 2023
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Dr. Weilin Liu

Bringing The Power Of Choice To Sequencing
Bringing The Power Of Choice To Sequencing
Bringing The Power Of Choice To Sequencing

Unleashing the Power of Genomic Sequencing: MGI's DNBSEQ™ Technology Revolution

In the dynamic field of genomic sequencing, MGI's DNBSEQ™ technology stands as a groundbreaking innovation, redefining efficiency, accuracy, and versatility in genetic research. This cutting-edge technology, integrated with MGI's advanced sequencing platforms and reagents, is revolutionizing genomic studies and research applications.

Introducing DNBSEQ™ Technology: A Milestone in Genomic Accuracy

MGI's DNBSEQ™ technology represents a significant leap in sequencing precision. Unlike traditional methods that rely on double-stranded linear DNA, DNBSEQ™ utilizes single-stranded DNA libraries. The core of this technology transforms single-stranded circular DNA into unique woolen ball-like structures, known as DNB nanoballs (DNBs). This transformation occurs through a specialized process called rolling circle replication, a method that sets DNBSEQ™ apart in the sequencing field.

Enhanced Features of DNBSEQ™:

  • Reduced Amplification Errors: The controlled enzymatic reaction intrinsic to rolling circle replication in DNBSEQ™ technology substantially minimizes amplification errors.

  • Unmatched Fidelity: DNBSEQ™ employs an enzyme with the highest known fidelity, ensuring precise and accurate replication of the original DNA template.

  • Prevention of Index Hopping: A critical advantage of DNBSEQ™ is its substantial reduction in index hopping rates, enhancing sample identification accuracy and utilization.

  • Superior Sensitivity in SNP and Indel Detection: DNBSEQ™ technology brings heightened accuracy and sensitivity to the detection of single nucleotide polymorphisms (SNPs) and insertions/deletions (indels).

MGI's Sequencing Solutions: DNBSEQ™ T7 and DNBSEQ™ G400 Platforms

The DNBSEQ™ T7 and DNBSEQ™ G400 are key pillars of MGI's sequencing ecosystem, embodying the innovative spirit of DNBSEQ™ technology.

DNBSEQ™ T7: High-Speed and High-Throughput Sequencing

  • Rapid Sequencing: The DNBSEQ™ T7 can complete a paired-end (PE) 100 sequencing run in a mere 22 hours, positioning it as one of the fastest sequencers available.

  • User-Oriented Design: It offers the flexibility to operate between one to four flow cells simultaneously and boasts a user-friendly touchscreen interface.

  • Impressive Data Production: The T7 can generate 1 to 4 terabases per day, with a single flow cell producing approximately 5,000 million reads.

DNBSEQ-T7
DNBSEQ-T7
DNBSEQ-T7

DNBSEQ-T7

High-Speed Precision in Genomic Sequencing

MGI's DNBSEQ-T7 revolutionizes genomic research with rapid, high-throughput sequencing. Capable of completing a PE 100 run in 22 hours and producing up to 4 terabases daily, this sequencer combines speed with precision, ideal for comprehensive genomic studies.

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DNBSEQ™ G400: Compact, Versatile Sequencing

  • Dual Flow Cell Operation: Processes SC50 dual flow cell runs in 16 hours, showcasing efficiency.

  • Flexible Data Output: Ranges from 75 to 720 gigabases per run, suitable for various applications.

  • Ideal for Benchtop Use: Its compact size makes it suitable for research and clinical use.

Noteworthy Update: Hot MPS Sequencing Reagents, No Longer Available

In 2022, MGI introduced significant enhancements to their Hot MPS sequencing chemistry, including engineered DNA polymerase and modified linkers and blockers. However, it's important to note that these Hot MPS sequencing reagents are no longer available.

Compatibility and Flexibility of MGI's Platforms

MGI's sequencing solutions are designed for broad compatibility with various library preparation kits, including third-party options. The MGI Easy Universal Library Conversion Kit enables efficient conversion for seamless integration with MGI's platforms.

Pioneering Genomic Research with DNBSEQ™

MGI's combination of DNBSEQ™ technology and sequencing platforms marks a significant advancement in genomic research. Catering to diverse research needs, from whole-genome sequencing to transcriptomics and single-cell studies, MGI's solutions offer unmatched efficiency and precision.

Researchers and institutions are invited to explore and adopt these innovative technologies in their genomic research, collaborating with MGI for further innovation and discovery.

Disclaimer: The information provided in this blog is for educational and informational purposes only and is not intended for use in diagnostic procedures. MGI products mentioned are for research use only.

DNBSEQ-G400
DNBSEQ-G400
DNBSEQ-G400

DNBSEQ-G400

Compact Versatility in Genomic Exploration

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Speakers

Dr. Weilin Liu
Dr. Weilin Liu
Dr. Weilin Liu

Dr. Weilin Liu

Field Application Scientist @MGI

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DNBSEQ™ technology

next-generation sequencing

genomic research

DNB NanoBalls

transcriptomic analysis

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Copyright © 2024 MGI tech GmbH, Ltd. All Rights Reserved.

Genomics Unlocked Background

Join our newsletter to stay up to date on our latest webinars.

Copyright © 2024 MGI tech GmbH, Ltd. All Rights Reserved.