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Immune Repertoire Profiling with DNBSEQ

26 oct. 2023
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Speakers,

:

Dr. Sean Huang

,

Dr. Yang Heng

,

Dr. Xiaojing Huo

,

Dr. John Beckford

,

Dr. Shaveta Goyal


Immune Repertoire Profiling with DNBSEQ
Immune Repertoire Profiling with DNBSEQ
Immune Repertoire Profiling with DNBSEQ

Immune Repertoire Profiling with DNBSEQ: Advancing Precision in Genomic Medicine

In the expansive domain of genomics and biomedical research, the ability to precisely sequence and interpret genetic material is a cornerstone of scientific advancement. As researchers endeavor to decode the intricate blueprints of DNA and RNA, state-of-the-art sequencing technologies such as the DNBSEQ-G99, T7, and G400 by MGI play a crucial role. These tools not only facilitate significant breakthroughs in fields like disease research and oncology but also empower the intricate process of immune repertoire profiling.

MGI Sequencers: A Beacon in Genomic Exploration

MGI, an affiliate of BGI Group, is at the forefront of genomic technology, renowned for developing sequencers that blend precision, scalability, and cost-effectiveness. This combination is essential for a broad spectrum of genomic applications, from basic research to complex immunogenetics studies.

Pioneering Immune Repertoire Profiling

Immune repertoire profiling is an intricate endeavor that examines the array of T-cell receptors (TCR) and B-cell receptors (BCR) within an organism. This analysis is pivotal for understanding the immune system’s nuanced responses to pathogens and diseases. By employing MGI's DNBSEQ technology, researchers gain the ability to conduct such profiling with unprecedented accuracy, offering deeper insights into the mechanisms underlying immune responses.

The Innovations of DNBSEQ Technology

MGI’s DNBSEQ technology is a transformative force in genomic sequencing. This technology facilitates a range of capabilities that are revolutionizing the field:

  • Precision in Immune Profiling: The DNBSEQ technology allows for detailed profiling of TCRs and BCRs, crucial for advancing our understanding of immunology and oncology.

  • Expansive Analytical Scope: With the capability to analyze large tissue sections — as extensive as half of a human brain — the DNBSEQ sequencers offer a comprehensive view that was previously unattainable.

  • Exceptional Spatial Resolution: Achieving sub-cellular resolution, this technology ensures that data pertaining to gene expression is meticulously captured, avoiding cross-contamination between adjacent data points.

This broad applicability of the DNBSEQ technology underscores its importance in a variety of research settings, from studying developmental biology in model organisms like axolotls to complex disease patterns in human tissues.

DNBSEQ-G99
DNBSEQ-G99
DNBSEQ-G99

DNBSEQ-G99

Advancing Genomic Insights in Immune Profiling

The DNBSEQ-G99 from MGI stands out in immune repertoire profiling, offering unmatched precision and efficiency. Its sequencing prowess is key to accurately analyzing T-cell and B-cell receptors, enhancing our understanding of the immune system's role in diseases and potential therapeutic pathways.

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Stereo-Seq: Bridging Genomic and Proteomic Worlds

While traditional gene expression analysis provides valuable insights, true understanding necessitates integrating genomic data with proteomic information. MGI’s Stereo-Seq technology addresses this need by allowing simultaneous detection of RNA and protein expressions within the same tissue sample, using sophisticated methods such as:

  • High-Plex Antibody Panels: These panels capture a broad spectrum of protein expressions, which are essential for comprehensive tissue analysis.

  • Innovative Capture Techniques: Utilizing poly-A tails and DNA barcodes, Stereo-Seq efficiently integrates RNA and protein data, enhancing the depth and breadth of biological insights.

Ensuring Data Integrity and Depth

Stereo-Seq not only expands the scope of data acquisition but also ensures its reliability and reproducibility across various samples. This consistency is crucial for the development of robust biological models and for the validation of experimental results.

Exploring New Frontiers in Tissue Analysis

The application of Stereo-Seq across different tissue types has demonstrated its versatility and power. From distinguishing cellular subtypes in human tissues to mapping intricate cellular interactions in model organisms, this technology illuminates various aspects of cellular biology, providing a richer understanding of biological processes.

Advancing Research with Multiomic Integration

Looking ahead, the integration of multiomic data holds the potential to redefine our approach to medical and biological research. By combining genomic and proteomic data, researchers can unlock new discoveries in cellular function, disease progression, and therapeutic targeting.

Conclusion: Shaping the Future of Genomic Research

The insights provided by the DNBSEQ technology, particularly through applications like immune repertoire profiling, are invaluable in the ongoing quest to understand and treat complex diseases. As genomic research continues to evolve, MGI’s sequencers remain essential tools, driving the innovations necessary to transform the future of medicine and science.

By delving into the molecular intricacies of cells and tissues with unprecedented detail and scale, researchers equipped with MGI's technology are setting new standards in precision medicine, heralding a new era of scientific discovery and medical breakthroughs.

DNBSEQ-T7
DNBSEQ-T7
DNBSEQ-T7

DNBSEQ-T7

Precision in Immune Repertoire Profiling

MGI's DNBSEQ-T7 is a vital tool for immune repertoire profiling in genomics and biomedical research. With its high-throughput sequencing capabilities, the T7 is adept at capturing intricate genetic variations, crucial for understanding immune responses and advancing fields like oncology and disease research.

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Speakers

Dr. Sean Huang - Director, Lab & Services - Precision Genomics @MiRXES
Dr. Sean Huang - Director, Lab & Services - Precision Genomics @MiRXES
Dr. Sean Huang - Director, Lab & Services - Precision Genomics @MiRXES

Dr. Sean Huang

Director, Lab & Services

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Dr. Yang Heng - Scientist @BGI Research
Dr. Yang Heng - Scientist @BGI Research
Dr. Yang Heng - Scientist @BGI Research

Dr. Yang Heng

Scientist @BGI Research

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Dr. Xiaojing Huo - Senior Product Manager @Singleron Biotechnologies
Dr. Xiaojing Huo - Senior Product Manager @Singleron Biotechnologies
Dr. Xiaojing Huo - Senior Product Manager @Singleron Biotechnologies

Dr. Xiaojing Huo

Senior Product Manager @Singleron Biotechnologies

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Dr. John Beckford - Scientist @Takara Bio
Dr. John Beckford - Scientist @Takara Bio
Dr. John Beckford - Scientist @Takara Bio

Dr. John Beckford

Scientist @Takara Bio

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Dr. Shaveta Goyal - Staff Scientist @Takara Bio
Dr. Shaveta Goyal - Staff Scientist @Takara Bio
Dr. Shaveta Goyal - Staff Scientist @Takara Bio

Dr. Shaveta Goyal

Staff Scientist @Takara Bio

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Genomics

Sequencing Technology

Immune Repertoire Profiling

MGI Sequencers

Multiomic Integration

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Copyright © 2024 MGI tech GmbH, Ltd. All Rights Reserved.

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Join our newsletter to stay up to date on our latest webinars.

Copyright © 2024 MGI tech GmbH, Ltd. All Rights Reserved.